The woman in the painting is commonly thought to be Lisa Gherardini.

The French emperor once had Mona Lisa hanging in his bedroom in the Tuileries Palace for about four years, beginning in 1800. It's said his fascination with the painting inspired his affection for a pretty Italian named Teresa Guadagni, who was actually a descendant of Lisa Gherardini.

In 1852, an artist named Luc Maspero supposedly threw himself from the fourth floor of a Parisian hotel, leaving a suicide note that read: "For years I have grappled desperately with her smile. I prefer to die."